|Skin Biology: New and Alternatives
ADVERSE EFFECTS OF VARIOUS AIR POLLUTANTS FOR HUMAN SKIN
Tsutomu IMAIZUMI, Kazuma SUDA, Yoichi HONMA
Department of Research and Development, Rohto Pharmaceutical Co., Ltd., Japan
As industry and human population are increasing, the problem of air pollution is increasing and getting worse. There are various types of air pollutants, for example, particulate matter 2.5, exhaust emission and house dust. These air pollutants have been well known to induce respiratory and cardiovascular diseases. Nowadays, attention has been focused on the effect of air pollutants to skin diseases, and people around the world are eager to reveal its molecular basis. In order to understand the effect of air pollutants to the skin, we evaluated air pollutants to normal human epidermal keratinocytes(NHEKs).
In this study, we used four air pollutants i.e. Vehicle Exhaust Particles, Urban Aerosols, Gobi Kosa Dust and Cender Pollen. Among four pollutants, two produced Reactive Oxygen Species(ROS) and another two did not. However, all of them increased the amount of Interleukin-8(IL-8) protein which is an inflammatory mediator. In order to understand the effect to skin in detail, we analyzed the gene expression in NHEKs after addition of air pollutants. All pollutants changed the gene expression related to inflammation, barrier function or others. All those results showed that air pollutants induced inflammation and other mechanisms in the skin.
Now, we are still investigating the mechanisms, and screening materials which are able to inhibit the effect of air pollutants to the skin.